Hepatitis A in Greater Florianópolis: analysis of the profile of cases and epidemiological indicators, 2023–2024

Authors

DOI:

https://doi.org/10.5327/DST-2177-8264-1450

Keywords:

hepatitis A, hepatitis A virus, disease outbreaks, health information systems

Abstract

Introduction: Despite improvements in sanitation and the introduction of the hepatitis A vaccine, sporadic outbreaks still occur in some regions of Brazil. Analysis of epidemiological indicators of hepatitis A in Greater Florianópolis allows for a more detailed understanding of the disease's characteristics in the local population, enabling the identification of more vulnerable groups and supporting targeted prevention and control strategies. Objective: To analyze the profile of cases and epidemiological indicators of hepatitis A in Greater Florianópolis during the period of 2023–2024. Methods: This is a descriptive study that analyzed confirmed cases of hepatitis A in Greater Florianópolis in 2023 and 2024. The profile was examined based on absolute and relative frequencies, accompanied by the calculation of incidence rates and sex ratios. Furthermore, Pearson's chi-square and Fisher's exact tests were used to examine differences in proportions. Results: There were 305 cases of hepatitis A registered. A higher frequency of notifications was observed in males (84.6%), in the age group of 20 to 39 years (79.3%), and in people with more schooling (45.9% with complete or incomplete higher education). The incidence of hepatitis A in Florianópolis was 35.0/100,000 inhabitants in 2023. Males showed a higher proportion of probable sexual transmission (66.8%) compared to females (25.0%), while females were more affected by contaminated water or food (75.0%) (p<0.001). Sexual transmission was more frequent in individuals with higher education (66.7%), while ingestion of contaminated water or food prevailed among those with primary education (28.6%) (p=0.017). Conclusion: The analysis of hepatitis A cases in Greater Florianópolis highlighted important differences in the epidemiological profile, with a higher frequency of cases in young, educated men, as well as distinct associations between transmission routes and sociodemographic factors, highlighting the need for specific prevention and control strategies.

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References

Secretaria de Estado da Saúde de Santa Catarina (SES/SC). Hepatite A [Internet]. Santa Catarina: Dive SC; 2023 [cited on 2024 Nov 04]. Available from: https://dive.sc.gov.br/index.php/doencas-e-agravos/hepatite-a

Workowski KA, Bolan GA, Centers for Disease Control and Prevention - CDC. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1-137.

Gloriani NG, de Paz-Silava SLM, Allison RD, Takashima Y, Avagyan T. The Shifting Epidemiology of Hepatitis A in the World Health Organization Western Pacific Region. Vaccines (Basel). 2024;12(2):204. https://doi.org/10.3390/vaccines12020204

Secretaria de Estado da Saúde de Santa Catarina – SES/SC. Nota informativa nº 011/2023 – LACEN/DIVE/SUV-SES/SC: orientações sobre a vigilância dos casos de hepatite A [Internet]. Florianópolis: SES/SC; 2023 [cited on 2024 Nov 04]. Available from: https://dive.sc.gov.br/phocadownload/notas-informativas/notas-informativas-2023/NI11.2023.pdf

Cao G, Jing W, Liu J, Liu M. The global trends and regional differences in incidence and mortality of hepatitis A from 1990 to 2019 and implications for its prevention. Hepatol Int. 2021;15(5):1068-82. https://doi.org/10.1007/s12072-021-10232-4

Carrilho FJ, Mendes Clemente C, da Silva LC. Epidemiology of hepatitis A and E virus infection in Brazil. Gastroenterol Hepatol. 2005;28(3):118-25. https://doi.org/10.1157/13072011

Brasil. Ministério da Saúde. Boletim Epidemiológico – Hepatites Virais 2024 [Internet]. Brasília: Ministério da Saúde; 2024 [cited on 2024 Nov 13]. Available from: https://www.gov.br/aids/pt-br/central-de-conteudo/boletins-epidemiologicos/2024/boletim-epidemiologico-hepatites-virais-2024/view

Brasil. Ministério da Saúde. Nota informativa nº 55/2019-CGAE/DIAHV/SVS/MS: orientações acerca dos critérios de definição de casos para notificações de hepatites virais [Internet]. Brasília: Ministério da Saúde; 2019 [cited on 2024 Nov 04]. Available from: https://portalsinan.saude.gov.br/images/documentos/Agravos/Hepatites_Virais/Nota_Informativa_Hepatites_Virais.pdf

Brasil. Ministério da Saúde. Resolução nº 674, de 6 de maio de 2022. Dispõe sobre a tipificação da pesquisa e a tramitação dos protocolos de pesquisa no Sistema CEP/Conep [Internet]. Brasília: Ministério da Saúde; 2022 [cited on 2024 Nov 04]. Available from: https://www.gov.br/conselho-nacional-de-saude/pt-br/atos-normativos/resolucoes/2022/resolucao-no-674.pdf/view

Leal PR, Guimarães RJPS, Kampel M. Sociodemographic and spatiotemporal profiles of hepatitis A in the state of Pará, Brazil, based on reported notified cases. Geospat Health. 2021;16(2). https://doi.org/10.4081/gh.2021.981

Urbanus AT, van Houdt R, van de Laar TJ, Coutinho RA. Viral hepatitis among men who have sex with men, epidemiology and public health consequences. Euro Surveill. 2009;14(47):19421. https://doi.org/10.2807/ese.14.47.19421-en

Hess KL, Crepaz N, Rose C, Purcell D, Paz-Bailey G. Trends in sexual behavior among men who have sex with men (MSM) in high-income countries, 1990–2013: a systematic review. AIDS Behav. 2017;21(10):2811-34. https://doi.org/10.1007/s10461-017-1799-1

Stene-Johansen K, Tjon G, Schreier E, Bremer V, Bruisten S, Ngui SL, et al. Molecular epidemiological studies show that hepatitis A virus is endemic among active homosexual men in Europe. J Med Virol. 2007;79(4):356-65. https://doi.org/10.1002/jmv.20781

Werber D, Michaelis K, Hausner M, Sissolak D, Wenzel J, Bitzegeio J, et al. Ongoing outbreaks of hepatitis A among men who have sex with men (MSM), Berlin, November 2016 to January 2017 – linked to other German cities and European countries. Euro Surveill. 2017;22(5):30457. https://doi.org/10.2807/1560-7917.es.2017.22.5.30457

Hofmeister MG, Gupta N, Hepatitis A Mortality Investigators. Preventable deaths during widespread community hepatitis A outbreaks - United States, 2016-2022. MMWR Morb Mortal Wkly Rep. 2023;72(42):1128-33. https://doi.org/10.15585/mmwr.mm7242a1

Horn EK, Herrera-Restrepo O, Acosta AM, Simon A, Jackson B, Lucas E. The burden of hepatitis A outbreaks in the United States: health outcomes, economic costs, and management strategies. J Infect Dis. 2024;230(1):e199-e218. https://doi.org/10.1093/infdis/jiae087

Gräf DD, Mesenburg MA, Fassa AG. Risky sexual behavior and associated factors in undergraduate students in a city in Southern Brazil. Rev Saúde Pública. 2020;54:41. https://doi.org/10.11606/s1518-8787.2020054001709

Bertoli RS, Scheidmantel CE, Carvalho NSD. Estudantes universitários e a infecção pelo HIV: um estudo sobre comportamento sexual e vulnerabilidades. DST. 2016;28(3):90-5.

Machado AM, Souza GCF, Teodoro GC, Fonseca LC, França RF. A falta de saneamento básico e sua relação com a hepatite A - uma abordagem descritiva sobre a doença. Rev Saúde Foco. 2021;13:32-50.

Silveira PO, Guasselli LA, Oliveira GG, Nascimento VF. Relationship between cases of hepatitis A and flood areas, municipality of Encantado, Rio Grande do Sul, Brazil. Cien Saude Colet. 2021;26(2):721-8. https://doi.org/10.1590/1413-81232020261.30592018

Brito WI, Souto FJD. Vacinação universal contra hepatite A no Brasil: análise da cobertura vacinal e da incidência cinco anos após a implantação do programa. Rev Bras Epidemiol. 2020;23:E200073. https://doi.org/10.1590/1980-549720200073

Brasil. Ministério da Saúde. Boletim Epidemiológico: Hepatites Virais 2018. Brasil: Ministério da Saúde; 2018.

Brasil. Ministério da Saúde. Hepatite A [Internet]. Brasília: Ministério da Saúde; 2025 [cited on 2025 Jan 20]. Available from: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/h/hepatites-virais/hepatite-a

Sociedade Brasileira de Infectologia. Imunossuprimidos [Internet]. São Paulo: Sociedade Brasileira de Infectologia; 2024 [cited on 2024 Nov 04]. Available from: https://infectologia.org.br/movimento-vacinacao/imunossuprimidos/?utm_source=chatgpt.com

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Published

2026-07-01

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1.
Valim RCS, Hillesheim D, Grando AV, de Oliveira EC, Pacheco SMS, Souza AJ de, et al. Hepatitis A in Greater Florianópolis: analysis of the profile of cases and epidemiological indicators, 2023–2024. DST [Internet]. 2026 Jul. 1 [cited 2026 Jul. 2];38. Available from: https://www.bjstd.org/revista/article/view/1450

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