What influence does vaginal microbiota have on Human Papillomavirus infection?

Authors

  • José Eleutério Junior
  • Rafael Pereira de Vasconcelos
  • Marina Mara Sousa de Oliveira
  • Renata Mírian Nunes Eleutério
  • Ana Katherine Silveira Gonçalves
  • Paulo César Giraldo

Keywords:

cervix uteri, microbiota, cervical intraepithelial neoplasia

Abstract

Introduction: The human body is colonized by trillions of microbial cells, called the microbiota. The microbiome is defined as microbial cells and their genomes. Vaginal microbiota, especially lactic acid bacteria (mainly Lactobacillus sp.), seem to play a critical role in the prevention of various urogenital diseases such as bacterial vaginosis, fungal infections, sexually transmitted diseases, urinary tract infections, and human papillomaviridae (HPV) infections. Changes in the vaginal microbiome contribute to the development of precancerous cervical lesions. Objective: To evaluate studies associating the vaginal microbiota with HPV, including the risk and persistence of infection and evolution to squamous intraepithelial lesions of the cervix. Methods: A systematic review was conducted based on articles published between September 2011 and September 2019, using the following keyword combinations: “HPV [All Fields] AND “microbiota” [MeSH Terms] OR “microbiota” [All Fields] OR “microbiome” [All Fields]).” The keyword search was performed in the MEDLINE, Latin American, and Caribbean Literature in Health Sciences (Lilacs), Cochrane Library, Highwire Stanford, and Embase databases. Results: In total, 239 original articles published between 2011 and 2019 were found in the researched databases on microbiome/microbiota and HPV. After exclusion, only six articles remained. Conclusion: There is a relationship between HPV and the cervicovaginal microbiota, but the mechanism of this influence cannot be specified.

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Author Biographies

José Eleutério Junior

Department of Women’s, Child and Adolescent Health, Universidade Federal do Ceará – Fortaleza (CE), Brazil.

Rafael Pereira de Vasconcelos

Faculty of Medicine, Universidade Federal do Ceará – Fortaleza (CE), Brazil.

Marina Mara Sousa de Oliveira

Master Course in Biomedical Sciences, Universidade da Beira Interior – Covilhã. Portugal.

Renata Mírian Nunes Eleutério

Biomedicine Course, Centro Universitário Christus – Fortaleza (CE), Brazil.

Ana Katherine Silveira Gonçalves

Department of Tocogynecology, Universidade Federal do Rio Grande do Norte – Natal (RN), Brazil.

Paulo César Giraldo

Department of Tocogynecology, Universidade Estadual de Campinas – Campinas (SP), Brazil.

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Published

2020-12-01

How to Cite

1.
Eleutério Junior J, Vasconcelos RP de, Oliveira MMS de, Eleutério RMN, Gonçalves AKS, Giraldo PC. What influence does vaginal microbiota have on Human Papillomavirus infection?. DST [Internet]. 2020 Dec. 1 [cited 2024 Mar. 28];32. Available from: https://www.bjstd.org/revista/article/view/893

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Original Article