Anal HPV preva lence in a cohort of individuals infected with HIV-1

Authors

  • Alcina Frederica Nicol
  • Nathalia Silva Oliveira
  • David William Provance Jr
  • Ruth K. Friedman
  • Valdileia Gonçalves Veloso
  • Jose Ricardo Coutinho
  • Cynthia Braga da Cunha
  • Dennis de Carvalho Ferreira

Keywords:

Papillomaviridae, vaccines, homosexuality, women, anal cancer

Abstract

Introduction: Human Papillomavirus (HPV) is the primary etiologic agent of anogenital tract cancer. A higher prevalence and incidence of developing cancer and diseases associated with HPV have been observed in individuals infected with the human immunodeficiency virus (HIV). The natural history of HPV infection has not been completely elucidated, as well as the immune response that occurs as coinfection with HIV/HPV, particularly in the anal mucosa. Objective: To analyze the HPV prevalence and clinical, epidemiological, and behavioral data in a cohort of HIV-seropositive individuals from the National Institute of Infectious Diseases, FIOCRUZ, RJ. Methods: The study included a total of 114 individuals from the histopathological diagnosis of anal biopsy. PCR and sequencing was performed for HPV DNA identification in anal discharge. Statistical analysis was performed using SPSS 15.0 software. Results: Patients Infected with HIV with anal intraepithelial neoplasia (AIN) II/III had nadir CD4 + <50 cells/mm³ compared to normal patients (p=0.01). The most prevalent HPV types in the anal secretion (by Papillocheck) were HPV 16 (29.2%), followed by HPV 52 (23.1%), both high-risk oncogenic, followed by HPV 44 and 55 (21.5%) that are low-risk type. A total of 53.3% HIV-infected individuals analyzed have already been exposed to the four HPV types targeted by the current quadrivalent vaccine (MSDm – HPV types 6, 11, 16, and 18). Conclusion: The data suggest that vaccination against HPV could be regarded as a prophylactic measure to reduce the risk of anal intraepithelial lesions in HIV-infected individuals.

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Author Biographies

Alcina Frederica Nicol

Laboratório Interdisciplinar de Pesquisas Médicas (LIPMED), IOC, Fiocruz – Rio de Janeiro (RJ), Brazil

Nathalia Silva Oliveira

Laboratório Interdisciplinar de Pesquisas Médicas (LIPMED), IOC, Fiocruz – Rio de Janeiro (RJ), Brazil

David William Provance Jr

Laboratório Interdisciplinar de Pesquisas Médicas (LIPMED), IOC, Fiocruz – Rio de Janeiro (RJ), Brazil. Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Instituto Nacional de Ciência e Tecnologia de Inovação em Doenças Negligenciadas (INCT-IDN), Fiocruz – Rio de Janeiro (RJ), Brazil.

Ruth K. Friedman

LapClin DST/AIDS, Instituto Nacional de Infectologia (INI), Fiocruz – Rio de Janeiro (RJ) Brazil

Valdileia Gonçalves Veloso

LapClin DST/AIDS, Instituto Nacional de Infectologia (INI), Fiocruz – Rio de Janeiro (RJ) Brazil

Jose Ricardo Coutinho

LapClin DST/AIDS, Instituto Nacional de Infectologia (INI), Fiocruz – Rio de Janeiro (RJ) Brazil

Cynthia Braga da Cunha

LapClin DST/AIDS, Instituto Nacional de Infectologia (INI), Fiocruz – Rio de Janeiro (RJ) Brazil

Dennis de Carvalho Ferreira

Department of Endodontics, Postgraduate Program in Dentistry, Universidade Estácio de Sá – Rio de Janeiro (RJ) Brazil.

Published

2022-04-20

How to Cite

1.
Nicol AF, Oliveira NS, Provance Jr DW, Friedman RK, Veloso VG, Coutinho JR, et al. Anal HPV preva lence in a cohort of individuals infected with HIV-1. DST [Internet]. 2022 Apr. 20 [cited 2024 Jul. 12];28(1):5-10. Available from: https://www.bjstd.org/revista/article/view/743

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Section

Original Article