Human papillomavirus in head and neck carcinomas

prevalence and clinicopathological relationship

Authors

  • Guilherme Petito
  • Sebastião Marcelino de Oliveira Júnior
  • Anamaria Donato de Castro Petito
  • Vera Aparecida Saddi

Keywords:

Papillomaviridae, head and neck neoplasm, epidemiology

Abstract

Introduction: The human papillomavirus (HPV), associated with other factors such as smoking and drinking, increases the risk of head and neck carcinomas. The presence of the HPV-16 genome, considered as highly carcinogenic, increases the risk by 50%. Objectives: To assess the prevalence and clinicopathological relationship of HPV associated with the head and neck carcinomas. Methods: This is a systematic literature review, from a bibliographical search on LILACS and MEDLINE databases. Results: Thirteen studies were reviewed, which altogether evaluated 1,216 cases of head and neck carcinomas, where HPV was detected, on average, in 36.45% of the cases. HPV-16 was the most prevalent genotype, present in 22 to 100% of positive cases for HPV. A higher prevalence of male subjects was observed in cases where the HPV genome was detected. A lower average age in HPV-positive cases was described in all the studies. An inverse association between the presence of HPV and habits such as smoking and alcohol consumption has been reported, with HPV seeming to be more prevalent in tumors presented by nonsmokers and nondrinkers. Conclusion: Despite being associated with smoking and alcohol consumption in some studies, improved prognosis and lower recurrence were reported in head and neck carcinomas with the presence of the HPV genome and a higher prevalence and growing incidence of these tumors in younger individuals.

Downloads

Download data is not yet available.

Author Biographies

Guilherme Petito

Master of Genetics, Pontifícia Universidade Católica de Goiás (PUC-GO), Professor at the Pharmacy Undergraduate Program – Ceres (GO), Brazil.

Sebastião Marcelino de Oliveira Júnior

Pharmacy Undergraduate Student, Faculdade FACER – Ceres (GO), Brazil.

Anamaria Donato de Castro Petito

Professor at the Nursing Undergraduate Course, Unievangélica – Ceres (GO), Brazil.

Vera Aparecida Saddi

Laboratory of Genetic Diversity, Pontifícia Universidade Católica de Goiás; Laboratory of Oncogenetics and Radiobiology, Associação de Combate ao Câncer em Goiás – Ceres (GO), Brasil.

Published

2022-04-20

How to Cite

1.
Petito G, Oliveira Júnior SM de, Petito AD de C, Saddi VA. Human papillomavirus in head and neck carcinomas: prevalence and clinicopathological relationship. DST [Internet]. 2022 Apr. 20 [cited 2024 Mar. 28];27(1-2):6-8. Available from: https://www.bjstd.org/revista/article/view/695

Issue

Section

Original Article